The Street & Smith multiverse is own known for the mysterious and and fantastic exploits of The Shadow and Doc Savage.
- Albert Palermo, criminal mastermind and foe of The Shadow.
- Alex Savage
- Andrew Mayfair, famous chemist and member of Doc Savage's mighty crew.
- Bert Crull, gunman for hire.
- Carlos Avispa, president of Hidalgo.
- Clark Savage, Sr., adventurer and father of Doc Savage.
- Clark Savage, Jr., famous scientist, adventurer, and all-around hero, commonly known as "Doc" Savage.
- Ezekiel Bingham, crooked lawyer whose crimes were investigated by The Shadow and Harry Vincent.
- Frank Marmosa
- Harry Vincent, one of The Shadow's earliest and most dogged agents.
- Hook McGuire, the bowling detective
- Isaac Coffran, dastardly criminal mastermind and foe of The Shadow.
- John Sunlight, one of Doc Savage's most deadly foes.
- Kent Allard, famed aviator and WWI spy, later the enigmatic vigilante The Shadow.
- Margo Lane, wealthy socialite and agent of The Shadow.
- Mike Larrigan
- Myra Reldon
- Nick Savoli
- Patricia Savage, younger cousin and associate of Doc Savage, with a taste for adventure
- Ralph Weston
- Shiwan Khan, final descendant of Genghis Khan and dogged foe of The Shadow
- Steve Cronin
- Theodore Brooks, maverick lawyer and member of Doc Savage's mighty crew.
- Vic Marquette
- Wainright Barth
- William Littlejohn
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